What are the latest advancements in shingles research?

July 31, 2024

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What are the latest advancements in shingles research?

Recent advancements in shingles research have brought promising developments in treatment and prevention strategies. Here are some key updates:

  1. mRNA-Based Shingles Vaccine: Pfizer and BioNTech have initiated a Phase 1/2 clinical trial for the first mRNA-based shingles vaccine. This innovative vaccine uses similar technology to the COVID-19 vaccines developed by the same companies. The mRNA vaccine encodes different versions of glycoprotein E (gE), a crucial component for the virus’s replication and spread. This approach aims to provide high efficacy, good tolerance, and efficient production compared to traditional vaccines​ (Pfizer)​.
  2. New Molecule for Treatment: Researchers at the University of Georgia have developed a new molecule, POM-L-BHDU, that shows promise in treating varicella-zoster virus infections, including shingles. This molecule can be formulated for oral, intravenous, or topical use, offering versatile treatment options. It targets the virus more directly, potentially reducing side effects and preventing the spread of the virus to other body areas. This molecule is currently undergoing testing, with plans for clinical trials​ (Med Xpress)​.
  3. Extended Efficacy of Shingrix Vaccine: Long-term data on the Shingrix vaccine (Recombinant Zoster Vaccine, RZV) have shown that it continues to provide high protection against shingles for more than a decade. The vaccine’s efficacy remains robust, with a 79.7% efficacy rate in individuals aged 50 and over, even 11 years post-vaccination. This extended protection underscores the importance of vaccination in preventing shingles, especially in older adults​ (Home | GSK )​.
  4. Potential Link to Reduced Dementia Risk: Emerging studies suggest that the shingles vaccine might also reduce the risk of dementia. This unexpected benefit highlights the vaccine’s potential role beyond preventing shingles, offering broader public health implications​ (Pfizer)​​ (ScienceDaily)​.

These advancements reflect ongoing efforts to improve shingles prevention and treatment, providing hope for better management and reduced complications associated with the disease. For more detailed information, you can refer to the latest research and clinical trial updates from reliable health sources.

 

How can one stay informed about new treatments for shingles?

Staying informed about new treatments for shingles involves accessing reliable sources, engaging with healthcare professionals, and utilizing various information channels. Here’s a comprehensive guide on how to keep up-to-date with the latest advancements:

**1. Professional Healthcare Consultations

a. Regular Check-Ups:

  • Maintain regular appointments with your healthcare provider, who can inform you about the latest treatments, clinical trials, and vaccines available. Doctors often have access to the most current medical research and guidelines.

b. Specialist Consultations:

  • If you are seeing a specialist, such as a dermatologist, neurologist, or infectious disease expert, they can provide specialized information about emerging treatments specific to shingles.

**2. Trusted Medical Websites and Journals

a. Reputable Medical Websites:

  • Websites like the Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), and Mayo Clinic regularly update their content with the latest medical research and treatment guidelines for various conditions, including shingles.

b. Medical Journals:

  • Access journals such as The New England Journal of Medicine, The Lancet, and JAMA Dermatology for peer-reviewed studies on shingles treatments. Many journals offer free access to abstracts or full articles, especially during public health crises.

c. Research Databases:

  • Utilize databases like PubMed, which index thousands of biomedical studies and articles. Searching for shingles or herpes zoster can yield the latest research findings and reviews.

**3. Clinical Trials and Research Studies

a. ClinicalTrials.gov:

  • This U.S. government database provides detailed information about clinical trials for various diseases, including shingles. You can find information on ongoing studies, eligibility criteria, and locations.

b. Participation in Clinical Trials:

  • Consider participating in clinical trials if eligible. This not only gives you access to new treatments but also contributes to the advancement of medical knowledge.

c. Updates from Pharmaceutical Companies:

  • Follow updates from pharmaceutical companies like Pfizer and GlaxoSmithKline, which are involved in developing new vaccines and treatments for shingles. These companies often release information about new drugs or clinical trials.

**4. Health News Outlets and Medical News Services

a. Health News Websites:

  • Websites like WebMD, Medscape, and Healthline offer news articles, expert interviews, and patient education materials. They often cover new drug approvals, research breakthroughs, and treatment guidelines.

b. Medical News Aggregators:

  • Use services like MedPage Today or Medical News Today, which aggregate medical news from various sources. These platforms can help you stay informed about the latest advancements in shingles treatment.

**5. Professional Organizations and Societies

a. American Academy of Dermatology (AAD):

  • The AAD provides updates on skin-related conditions, including shingles. They publish guidelines, research, and news relevant to dermatology.

b. American Academy of Neurology (AAN):

  • For those experiencing neurological complications from shingles, the AAN offers resources and updates on the latest treatments and research in neurology.

c. Infectious Diseases Society of America (IDSA):

  • The IDSA provides information on infectious diseases, including shingles. They offer updates on treatment guidelines, research, and vaccine recommendations.

**6. Social Media and Online Forums

a. Follow Healthcare Professionals:

  • Many doctors, researchers, and healthcare institutions share insights and updates on social media platforms like Twitter, LinkedIn, and Facebook. Following reputable professionals can provide real-time information.

b. Online Support Groups and Forums:

  • Engage in online communities where individuals discuss their experiences with shingles treatments. Websites like Reddit or patient forums on HealthUnlocked can be valuable for anecdotal information and peer support.

**7. Patient Advocacy Groups and Non-Profit Organizations

a. Shingles Advocacy and Support Groups:

  • Organizations dedicated to supporting individuals with shingles can provide resources, newsletters, and updates about new treatments. Examples include the National Shingles Foundation.

b. Vaccine Advocacy Groups:

  • Groups focused on vaccine awareness and education can offer information on shingles vaccines, including the latest research on vaccine efficacy and availability.

**8. Continuing Education and Public Health Announcements

a. Webinars and Online Courses:

  • Some organizations and medical institutions offer webinars and online courses on topics related to shingles. These can be a valuable way to learn about new treatments from experts in the field.

b. Public Health Announcements:

  • Keep an eye on public health announcements from national health agencies, which often disseminate new guidelines or recommendations for shingles treatment and prevention.

**9. Technology and Apps

a. Health Apps:

  • There are several health apps available that can provide updates on medical news, including new treatments for shingles. Apps like Medscape or Epocrates can offer drug information, clinical guidelines, and medical news alerts.

b. Alerts and Newsletters:

  • Subscribe to newsletters or set up news alerts on platforms like Google News to receive updates on shingles treatment advancements directly in your inbox.

**10. Consultation with Pharmacists

a. Local Pharmacy:

  • Pharmacists can be a valuable resource for information on the latest medications, including over-the-counter and prescription options for shingles treatment.

b. Specialty Pharmacies:

  • Specialty pharmacies often have more detailed information about complex treatments and can provide patient education materials on new drugs.

By utilizing these resources and staying proactive, you can stay informed about the latest treatments for shingles and make well-informed decisions about your care. Always consult with healthcare professionals before starting new treatments or making changes to your existing regimen.

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